联系专家

高荣 博士,教授,博士生导师

四川大学 自然科学类 生物学 人气:
概况四川省学术和技术带头人四川大学生物资源与生态环境教育部重点实验室副主任;四川省动物预防医学分会秘书长;《Biomaterial》、《Vaccine》、《Immunology》、《Nanomedicine》和《ResearchinVeterinaryScience》等国际SCI学术期特邀刊审稿专家;学习和工作简历:1981.09-1985.07:动物医学本科毕业,学士;1985.9-1988.6:免疫病理硕士研究生,硕士;1988.07-1991.07:硕士,参加工作;助教…

概况

四川省学术和技术带头人

四川大学生物资源与生态环境教育部重点实验室副主任;
四川省动物预防医学分会秘书长;
《Biomaterial》、《Vaccine》、《Immunology》、《Nanomedicine》和《Research in Veterinary Science》等国际SCI学术期特邀刊审稿专家; 
学习和工作简历:
1981.09-1985.07:动物医学本科毕业,学士;
1985.9-1988.6:免疫病理硕士研究生, 硕士
1988.07-1991.07: 硕士,参加工作;助教、讲师;
1991.09-1994.12: 讲师;在职博士研究生,博士; 
1995.01-1996.02:东北农业大学,副教授;
1996.03-至今:四川大学生命科学学院,副教授,教授;
2004.11:访问美国Missouri University、Stanford University、Kansas University,California University in Los Angeles and San Francisco,California Institute of Technology、
2005-2006年:到澳大利亚Melbourne University、Victoria University、Monash University、美国Harvard University、Massachusetts Institute of Technology、Boston University、Washington University 、Maryland University访问与学术交流;;
2007-2008年:丹麦Denmark Technical University访问学者、到Copenhagen University、英国Cambridge University、Oxford University学术交流与合作研究;
2009.06-09:到比利时Veterinary and Agrochemical research Centre、德国Hannover University和新加坡国立大学访问和学术交流;
2010年:到德国Leipzig University、法国的ONCFS研究所、美国 California University of Berkley、California University of San Diego、Chicago University、Massachusetts Institute of Technology访问与学术交流;
2011.11:访问西班牙Barcelona University 、Olot Pfizer company和瑞士IVI(Institute of Virology and Immunoprophylaxis)和学术交流;

代表成果

Dong Li, Jian-Lin Chen, Huan Zhang,Xiao Yang, Xiao-Ping Wan, Chi Cheng, Yue Li, Ze-Zhou Wang, Xue-Bin Lv, Hong-Ning Wang, Jiang-Ling Li, Rong Gao,Improvement of the immunity of pig to Hog cholera vaccine by recombinant plasmid with porcine interleukin-6 gene and CpG motifs,Vaccine,2011,29,3888–3894 (corresponding author)

Yuanyuan Yu, Zheng Wang, Lin Cai, Gang Wang, Xiao Yang, Xiao Pin Wan, Xin Hua Xu,Ying Li, Rong Gao. Synthesis and characterization of methoxy poly(ethylene glycol)-O-chitosan-polyethylenimine for gene delivery,Carbohydrate Polymers ,2010,81 (2): 269-274(corresponding author)

Yang, X Sun, WK Chen, WL Chen, JL Wan, XP Zhang, H  Cai, L Wang, ZZ Lv, XB Wang, HN Li, JL Gao, R. Promotion of the immunity of piglets to Hog cholera vaccine induced by shuffled pig interleukin-2 gene and CpG immunostimulatory sequences encapsulated in chitosan nanoparticles,Procedia in Vaccinology,2010, 2 (1): 51-59(corresponding author)

Zhong-Zhong Zhao, Hua-Bing Zhang , Qian Chen, Zhao Xie, Ying-Yu Wang, Yi Yang, Ze-Zhou Wang , Jiang-Ling Li, Kai-Yuan Wu , Hong-Ning Wang, Min-Jie Meng , Rong Gao, Promotion of immunity of mice to Pasteurella multocida and Hog cholera vaccine by pig interleukin-6 gene and CpG motifs, Comparative Immunology, Microbiology & Infectious Diseases, 2009,32:191-205(corresponding author)

Zhigang Xu , Xiaoping Wan, Wei Zhang, Zheng Wang , Lin Cai , Ying Li, Qing Jiang, Rong Gao, Synthesis of biodegradable polycationic methoxy poly(ethylene glycol)–polyethylenimine–chitosan and its potential as gene carrier, Carbohydrate Polymers, 2009,78(1):46-53(corresponding author)

Baofeng Song, Wei Zhang, Rong Peng , Jie Huang , Ting Nie, Ying Li*, Qing Jiang, Rong Gao,  Synthesis and cell activity of novel galactosylated chitosan as a gene carrier, Colloids and Surfaces B:Biointerfaces, 2009, 70:181-186(corresponding author)

Tao Zhang,Yuan Yuan Yu, Dong Li,Rong Peng,Ying Li,Qing Jiang,Ping Dai,Rong Gao*,Synthesis and properties of a novel methoxy poly(ethylene glycol)- modified galactosylated chitosan derivative,J Mater Sci: Mater Med,2009,20(3): 673-680(corresponding author)

Qian Chen, Zhong-Zhong Zhao, Rong Peng,Ying-Yu Wang, Zhao Xie, Ze-Zhou Wang, Rong Gao* ,Enhancement of immunity and resistance in mice by pig IL-6 gene and CpG motifs encapsulated in chitosan nanoparticle,Biotechnology Journal , 2008, 3(2):264-273(corresponding author)

Zhao Xie , Hui Li, Jianlin Chen, Hua-bing Zhang, Qian Chen, Zhong-Zhong Zhao, Chi Cheng, Huan Zhang, Yi Yang, Rong Gao, Shuffling of pig interleukin-2 gene and its enhancing of immunity in mice to Pasteurella multocida vaccine, Vaccine, 2007 25 :8163–8171(corresponding author)

Huan Zhang, Chi Cheng, Min Zheng, Zhao Xie, Jiang Ling Li, Yi Yang, Yi Shen, Hong-Ning Wang,Zezhou Wang, Rong Gao, Enhancement of immunity to an Escherichia coli  vaccine in mice orally inoculated with a fusion  gene encoding porcine interleukin 4 and 6, Vaccine, 2007, 25: 7094–7101(corresponding author)

Yi Yang, Jianlin Chen, Hui Li, Yingyi Wang, Zhao Xie, Huan Zhang, Cheng Chi, Hongning Wang, Rong Gao, Porcine interleukin-2 gene encapsulated in chitosan nanoparticles enhances immune response of mice to piglet paratyphoid vaccine, Comparative Immunology, Microbiology & Infectious Diseases, 2007,30(1):19-32 (corresponding author)

Wu Kaiyuan, Wu Mei, Fu Manliang, Gao Rong, A novel CpG chitosan nanoparticles to regulate the cellular and humoral immunity of mice.  Biomedical and Environmental Sciences,2006,19(2):87-95(corresponding author)

Man-Liang FU, Sancheng Ying, Mei Wu, Hui Li, Rong Gao, Regulating effects of a novel CpG Chitosan-nanoparticles on immune responses to porcine paratyphoid vaccines in mice, Biomedical and Environmental Sciences,2006,19(4):315-322 (corresponding author)

Hui Li, Shigui Liu, Lihuan Wang, Rong Gao et al. Molecular Cloning and Expression of IL2 cDNA from Tibet Pig,Veterinary Research communication, 2005, 29:395-405 (corresponding author)

Mei Wu, Shigui Liu, Bing Shen, Minjie Meng, Rong Gao et al. Regulating effects of porcine interleukin-6 gene and CpG motifs on immune responses to porcine trivalent vaccines in mice. Res. Vet .Sci. 2004,77:49-57(corresponding author)

Jinling Li, Shigui Liu, Bing Shen, Minjie Meng, Rong Gao et al. The immunoregulation of mice by somatic transgenic expression of porcine interleukin-6 and CpG sequence. Veterinary Research Communication,2004,28:33-46 (corresponding author)

Mei Wu,Lin Shu,Rong Gao,Shigui Liu et al, The Effect of Entrapment of Murine Interleukin 2 Gene with Chitosan Nanoparticles on the Expression and Its Regulation of Immune Response of Mice, Journal of biomedical engineering,2004,6:947-952 

Manliang Fu, Hui Li, Kaiyuan Wu, Rong Gao et al. Molecular Cloning and Expression of IL2 cDNA from Yak, Sichuan Journal of Zoology, 2005, 24:507-512(corresponding author)

Shen Bin, Gao Rong, Men Mingjie, Shigui Liu et al, Immune response of mice to inoculation with TS11 antigenic gene of Taenia Solium, Chinese J. Veterinary Medicine, 2004,1:3-6

Li Hui,Gao Rong*,Wu Mei, Shigui Liu et al,Cloning and sequence analysis of γ-interferon gene from Tibet pig, Chinese Vet. Science and Technology, 2003,5:48-51 

Shen Bin, Gao Rong, Men Mingjie, Shigui Liu et al, The eukaryotic expression of TS11 antigenic gene from cysticircus cellulosae, Chinese J.Vet. Medicine,2003,4: 6-9

Li Hui,Gao Rong*,Wu mei,Ding Xiaotao, Shigui Liu et al, Cloning and Analyzing of  interleukin-4 cDNA from the lymphocyte of Tibet Pig, Chinese J. Immunology, 2003,6:475-478 

Long Zhangfu, Gao Rong, Men Mingjie, et al, Effect of porcine interleukin gene 6 entrapped with cationic liposome on the immune responses of mice inoculated with the antigenic gene  vaccine of Taenia Solium, High Technology Letters, 2003.3:25-29

Lv Xuebing, Li Jianglin, Gao Rong, et al, Effect of transgenic expression of  PIFN-γgene on the immune responses of mice immunization with paratyphoid vaccine, High technology letter,2003.4:236 

Ning Hong, Gao Rong, Qin Zhen, Shigui Liu et al, Analysis of the protein electrophoresis patterns of Curvularia lunata in maize and immunological detection of the pathogenic culture, High technology Communication,2002.3:11-15

Mei Wu, Rong Gao, Jiangling Li, Minjie Meng, Shigui Liu et al. Regulating Effect of CpG Motifs and Cationic Liposome on Immune Responses to Antigenic Gene of Taenia solium in Mice, High Technology Letters, 2002, 7: 39-44

Jiangling Li, Rong Gao, Mei Wu , Mingjie Meng, Shigui Liu et al., The effect of transgenic expression of porcine interleukin-6 gene and CpG sequences on immune responses of mice inoculated with the gene vaccine of Taenia solium of pig.  High Technology  Letters, 2002, 6: 26-30

Wang Zezhou, Gao Rong, Yang Lin, Shigui Liu et al, Construction and Expression of fusion gene of somatostatin and Hepatitis B surface antigen gene in Yeast Pichia Pastoris, Journal of biomedical engineering (EI), 2002,3:483

Meng Minjie, Gao Rong, Tang Manshu, Li Jiang, et al, Cloning and sequencing of porcine interleukin –6 gene from lymphocyte, J. Sichuan University ( natural science edition), 2002, 3:557-560 

研究领域

研究方向包括:分子遗传和基因工程、分子免疫学、生物技术、微生物学和动物传染病;主要开展动物表观遗传学、动物分子免疫、动物生长发育和代谢调节、新疫苗研制、免疫应答调节和新型抗感染免疫分子制剂的研究探索;
着重利用我国丰富的生物基因资源,克隆分离免疫抗感染、生长发育和代谢调控相关功能基因和分子,鉴定其功能活性;以现代分子生物学、遗传学、分子免疫学、生物信息学和结构生物学等理论为指导,用生物工程技术修饰和改造生物分子结构,提高其生物调节活性;结合纳米生物材料技术,研制协调增强动物免疫防御、抗应激和促进动物生长发育和代谢调节的系列新型分子制剂;防治传染性疾病,控制微生物感染,调节动物生长发育、保障和促进动物健康生长,并改善动物营养成分,提高其营养价值。

大事记

1994:鸡传染性法氏囊病的免疫机理,省科技进步二等奖,省教委科技进步一等奖,
1996:鸡马立克氏病及其疫苗的免疫机理,省科技进步二等奖,省教委科技进步一等奖;
1997:小日龄火鸡新城疫免疫机理研究,省教委科技进步一等奖;
2000:囊虫病防治关键技术研究,省科技进步二等奖;
2010:猪用DNA分子免疫调节新技术研究,省科技进步二等奖;
2004-2006:四川大学展虹奖研金二等奖;
2003-2005:四川大学青年骨干教师奖;
2003年:入选四川大学“214人才”计划第三层次人才;
2004年:入选“四川省杰出青年学科带头人培养计划;
2008年:四川省学术和技术带头人

项目

  1. 科技部国际合作项目,猪瘟防控新疫苗免疫机理及其免疫调控研究 European Commission, SEVENTH FRAMEWORK, PROGRAMME Grant agreement no.: 227003 CP-FP(欧盟国际合作项目),Improve tools and strategies for the prevention and control of classical swine fever.
  2. 国家863计划,家禽重要病毒病基因工程疫苗研究和创制.
  3. 国家科技支撑计划,动物产品兽药残留安全控制技术研究.
  4. 国家科技支撑计划,猪瘟及口蹄疫流行病学和快速诊断技术集成研究.
  5. 国家重大项目前期基础研究,生物技术筛选高原植物活性分子及消除细菌耐药性的研究.
  6. 国家自然科学基金,猪白细胞介素-23基因克隆表达及其对猪免疫记忆的效应研究.
  7. 国家自然科学基金,猪新型免疫基因转体细胞表达的免疫调节效应.
  8. 国家自然科学基金,猪白细胞介素2和6基因的改组研究.
  9. 国家自然科学基金,鸡传染性贫血的免疫机理.
  10. 国家自然科学基金,鸡马立克氏病及疫苗的免疫机理.

论文

  1. Dong Li, Jian-Lin Chen, Huan Zhang,Xiao Yang, Xiao-Ping Wan, Chi Cheng, Yue Li, Ze-Zhou Wang, Xue-Bin Lv, Hong-Ning Wang, Jiang-Ling Li, Rong Gao,Improvement of the immunity of pig to Hog cholera vaccine by recombinant plasmid with porcine interleukin-6 gene and CpG motifs,Vaccine,2011,29,3888–3894 (corresponding author).
  2. Yuanyuan Yu, Zheng Wang, Lin Cai, Gang Wang, Xiao Yang, Xiao Pin Wan, Xin Hua Xu,Ying Li, Rong Gao. Synthesis and characterization of methoxy poly(ethylene glycol)-O-chitosan-polyethylenimine for gene delivery,Carbohydrate Polymers ,2010,81 (2): 269-274(corresponding author).
  3. Yang, X Sun, WK Chen, WL Chen, JL Wan, XP Zhang, H Cai, L Wang, ZZ Lv, XB Wang, HN Li, JL Gao, R. Promotion of the immunity of piglets to Hog cholera vaccine induced by shuffled pig interleukin-2 gene and CpG immunostimulatory sequences encapsulated in chitosan nanoparticles,Procedia in Vaccinology,2010, 2 (1): 51-59(corresponding author).
  4. Zhong-Zhong Zhao, Hua-Bing Zhang , Qian Chen, Zhao Xie, Ying-Yu Wang, Yi Yang, Ze-Zhou Wang , Jiang-Ling Li, Kai-Yuan Wu , Hong-Ning Wang, Min-Jie Meng , Rong Gao, Promotion of immunity of mice to Pasteurella multocida and Hog cholera vaccine by pig interleukin-6 gene and CpG motifs, Comparative Immunology, Microbiology & Infectious Diseases, 2009,32:191-205(corresponding author).
  5. Zhigang Xu , Xiaoping Wan, Wei Zhang, Zheng Wang , Lin Cai , Ying Li, Qing Jiang, Rong Gao, Synthesis of biodegradable polycationic methoxy poly(ethylene glycol)–polyethylenimine–chitosan and its potential as gene carrier, Carbohydrate Polymers, 2009,78(1):46-53(corresponding author).
  6. Baofeng Song, Wei Zhang, Rong Peng , Jie Huang , Ting Nie, Ying Li*, Qing Jiang, Rong Gao, Synthesis and cell activity of novel galactosylated chitosan as a gene carrier, Colloids and Surfaces B:Biointerfaces, 2009, 70:181-186(corresponding author).
  7. Tao Zhang,Yuan Yuan Yu, Dong Li,Rong Peng,Ying Li,Qing Jiang,Ping Dai,Rong Gao*,Synthesis and properties of a novel methoxy poly(ethylene glycol)- modified galactosylated chitosan derivative,J Mater Sci: Mater Med,2009,20(3): 673-680(corresponding author).
  8. Qian Chen, Zhong-Zhong Zhao, Rong Peng,Ying-Yu Wang, Zhao Xie, Ze-Zhou Wang, Rong Gao* ,Enhancement of immunity and resistance in mice by pig IL-6 gene and CpG motifs encapsulated in chitosan nanoparticle,Biotechnology Journal , 2008, 3(2):264-273(corresponding author).
  9. Zhao Xie , Hui Li, Jianlin Chen, Hua-bing Zhang, Qian Chen, Zhong-Zhong Zhao, Chi Cheng, Huan Zhang, Yi Yang, Rong Gao, Shuffling of pig interleukin-2 gene and its enhancing of immunity in mice to Pasteurella multocida vaccine, Vaccine, 2007 25 :8163–8171(corresponding author).
  10. Huan Zhang, Chi Cheng, Min Zheng, Zhao Xie, Jiang Ling Li, Yi Yang, Yi Shen, Hong-Ning Wang,Zezhou Wang, Rong Gao, Enhancement of immunity to an Escherichia coli vaccine in mice orally inoculated with a fusion gene encoding porcine interleukin 4 and 6, Vaccine, 2007, 25: 7094–7101(corresponding author).
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